
In his book Rendell points out Pantani was absolutely unable to cope with the amounts of attention his every move received in the media and the pressure to win from his fans. After the doping scandals he was involved in, shame and "the weight of the world on his shoulders" made his tendency to self destruct overpower his will to live.
Pantani's "tragic hero" life story does not stand on itself. In sports, but even more so in music, there are many examples of artists who are mentally unable to deal with excessive (media) attention and fame. It seems that some sort of internal mechanism kicks into gear that just wants to destroy whatever has been achieved, instead of enjoying it or expanding it. More recently, Amy Winehouse seems to be following the same path as Pantani, or Janis Joplin, Jimi Hendrix, Kurt Cobain, Ian Curtis (pic), the list goes on and on.

Why is this self-destruction mechanism present in some of us, and not all of us? I could name many artists in history that have lead a long life, died of natural causes and left a legacy of great inspirational works of art. To go back to Marco Pantani, Rendell's book points out that in Marco's childhood there were already clues of bi-polar disorder and manic depression, and that his jump to fame only accelerated the symptoms. So there must have been something at the root of it all. In other "tragic hero" stories you will find childhood/early teen experiences that explain the final chapter of one's life.
It is an assumption, but perhaps fame is not the cause for someone's demise, but merely the catalyst and accelerator of an already existing mental issue. So there is no escape. The tragic hero is doomed from the start.

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